HECA-452

Antibody IDAN0032
Epitope ID EP0012
Epitope nameSialyl Lewis x
Recognition regionNeu5Ac(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-)-R
Neu5Ac(a2-3)[HSO3(-6)]Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-)-R
Neu5Ac(a2-3)Gal(b1-4)[Fuc(a1-3)][HSO3(-6)]GlcNAc(b1-3)Gal(b1-)-R
Neu5Ac(a2-3)[HSO3(-6)]Gal(b1-4)[Fuc(a1-3)][HSO3(-6)]GlcNAc(b1-3)Gal(b1-)-R
Immunoprecipitation[2]
Immunoblot[3]
ELISA/RIA
Flow cytometry
Histochemistry[1][4]
Comment
Epitope ID EP0014
Epitope name6'-Sulfo Sialyl Lewis x
Recognition regionNeu5Ac(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-)-R
Neu5Ac(a2-3)[HSO3(-6)]Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-)-R
Neu5Ac(a2-3)Gal(b1-4)[Fuc(a1-3)][HSO3(-6)]GlcNAc(b1-3)Gal(b1-)-R
Neu5Ac(a2-3)[HSO3(-6)]Gal(b1-4)[Fuc(a1-3)][HSO3(-6)]GlcNAc(b1-3)Gal(b1-)-R
Immunoprecipitation[2]
Immunoblot[3]
ELISA/RIA
Flow cytometry
Histochemistry[1][4]
Comment
Epitope ID EP0015
Epitope nameSialyl 6-Sulfo Lewis x
Recognition regionNeu5Ac(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-)-R
Neu5Ac(a2-3)[HSO3(-6)]Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-)-R
Neu5Ac(a2-3)Gal(b1-4)[Fuc(a1-3)][HSO3(-6)]GlcNAc(b1-3)Gal(b1-)-R
Neu5Ac(a2-3)[HSO3(-6)]Gal(b1-4)[Fuc(a1-3)][HSO3(-6)]GlcNAc(b1-3)Gal(b1-)-R
Immunoprecipitation[2]
Immunoblot[3]
ELISA/RIA
Flow cytometry
Histochemistry[1][4]
Comment
Epitope ID EP0016
Epitope name6,6'- Disulfo Sialyl Lewis x
Recognition regionNeu5Ac(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-)-R
Neu5Ac(a2-3)[HSO3(-6)]Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-)-R
Neu5Ac(a2-3)Gal(b1-4)[Fuc(a1-3)][HSO3(-6)]GlcNAc(b1-3)Gal(b1-)-R
Neu5Ac(a2-3)[HSO3(-6)]Gal(b1-4)[Fuc(a1-3)][HSO3(-6)]GlcNAc(b1-3)Gal(b1-)-R
Immunoprecipitation[2]
Immunoblot[3]
ELISA/RIA
Flow cytometry
Histochemistry[1]
Comment
SpeciesMouse
CategoryMonoclonal
IsotypeIgM
Immunogen
Availability
Applications
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1 Renkonen J, Tynninen O, Hayry P, Paavonen T, Renkonen R.
Glycosylation might provide endothelial zip codes for organ-specific leukocyte traffic into inflammatory sites.
Am J Pathol. 2002 Aug ;161(2):543-50
PMID: 12163379
2 Cai S, Davis AE 3rd.
Complement regulatory protein C1 inhibitor binds to selectins and interferes with endothelial-leukocyte adhesion.
J Immunol. 2003 Nov 1;171(9):4786-91
PMID: 14568956
3 Tu L, Murphy PG, Li X, Tedder TF.
L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1.
J Immunol. 1999 Nov 1;163(9):5070-8
PMID: 10528213
4 Wagers AJ, Stoolman LM, Kannagi R, Craig R, Kansas GS.
Expression of leukocyte fucosyltransferases regulates binding to E-selectin: relationship to previously implicated carbohydrate epitopes.
J Immunol. 1997 Aug 15;159(4):1917-29
PMID: 9257857