5F4

Antibody IDAN0069
Epitope ID EP0021
Epitope nameTn Antigen
Recognition regionGalNAc(a1-)Ser/Thr
Immunoprecipitation
Immunoblot
ELISA/RIA
Flow cytometry[2]
Histochemistry[1][3]
Comment
SpeciesMouse
CategoryMonoclonal
IsotypeIgM
Immunogen
Availability
Applications
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1 Thurnher M, Clausen H, Sharon N, Berger EG.
Use of O-glycosylation-defective human lymphoid cell lines and flow cytometry to delineate the specificity of Moluccella laevis lectin and monoclonal antibody 5F4 for the Tn antigen (GalNAc alpha 1-O-Ser/Thr).
Immunol Lett. 1993 Jun ;36(3):239-43
PMID: 8370596
2 Ragupathi G, Liu NX, Musselli C, Powell S, Lloyd K, Livingston PO.
Antibodies against tumor cell glycolipids and proteins, but not mucins, mediate complement-dependent cytotoxicity.
J Immunol. 2005 May 1;174(9):5706-12
PMID: 15843572
3 Rajpert-De Meyts E, Poll SN, Goukasian I, Jeanneau C, Herlihy AS, Bennett EP, Skakkebaek NE, Clausen H, Giwercman A, Mandel U.
Changes in the profile of simple mucin-type O-glycans and polypeptide GalNAc-transferases in human testis and testicular neoplasms are associated with germ cell maturation and tumour differentiation.
Virchows Arch. 2007 Oct ;451(4):805-14
PMID: 17694322