NS19-9

Antibody IDAN0107
Epitope ID EP0008
Epitope nameSialyl Lewis a
Recognition regionNeu5Ac(a2-3)Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-)-R
Immunoprecipitation
Immunoblot[4][8][7]
ELISA/RIA[5*][7][6][9]
Flow cytometry
Histochemistry[1][2][10]
Comment
SpeciesMouse
CategoryMonoclonal
IsotypeIgG1
ImmunogenSW1116/human colon adenocarcinoma[11][3]
AvailabilityTFB,INC.
ApplicationsThe monoclonal antibody NS 19-9 is a representative diagnostic agent for pancreatic adenocarcinoma and cholangiocellular cancer.
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1 Nakayama T, Watanabe M, Katsumata T, Teramoto T, Kitajima M.
Expression of sialyl Lewis(a) as a new prognostic factor for patients with advanced colorectal carcinoma.
Cancer. 1995 Apr 15;75(8):2051-6
PMID: 7697593
2 Macdonald F, Bird R, Stokes H, Russell B, Crocker J.
Expression of CEA, CA125, CA19-9 and human milk fat globule membrane antigen in ovarian tumours.
J Clin Pathol. 1988 Mar ;41(3):260-4
PMID: 3162916
3 Magnani JL, Nilsson B, Brockhaus M, Zopf D, Steplewski Z, Koprowski H, Ginsburg V.
A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II.
J Biol Chem. 1982 Dec 10;257(23):14365-9
PMID: 7142214
4 Chang TH, Steplewski Z, Sears HF, Koprowski H.
Detection of monoclonal antibody-defined colorectal carcinoma antigen by solid-phase binding inhibition radioimmunoassay.
Hybridoma. 1981 ;1(1):37-45
PMID: 6926850
5 Kitagawa H, Nakada H, Numata Y, Kurosaka A, Fukui S, Funakoshi I, Kawasaki T, Shimada I, Inagaki F, Yamashina I.
Occurrence of tetra- and pentasaccharides with the sialyl-Le(a) structure in human milk.
J Biol Chem. 1990 Mar 25;265(9):4859-62
PMID: 2318868
6 Kannagi R, Takada A, Shigeta K, Itai S, Hashimoto K.
[2D3 series, MSW 113 and other monoclonal antibodies directed to type 1 chain carbohydrate antigens]
Nippon Rinsho. 1990 Feb ;48 Suppl:992-8
PMID: 2355641
7 Fukuta S, Magnani JL, Gaur PK, Ginsburg V.
Monoclonal antibody CC3C195, which detects cancer-associated antigens in serum, binds to the human Lea blood group antigen and to its sialylated derivative.
Arch Biochem Biophys. 1987 May 15;255(1):214-6
PMID: 3592664
8 Kano Y, Taniguchi T, Uemura Y, Yokoyama K, Ohyanagi H, Saitoh Y.
Selection of monoclonal antibodies detecting KM01 antigen.
Tohoku J Exp Med. 1990 Oct ;162(2):127-36
PMID: 2097812
9 Kitagawa H, Nakada H, Numata Y, Kurosaka A, Fukui S, Funakoshi I, Kawasaki T, Yamashina I.
A monoclonal antibody that recognizes sialyl-Lea oligosaccharide, but is distinct from NS 19-9 as to epitope recognition.
J Biochem. 1988 Nov ;104(5):817-21
PMID: 2466827
10 Chung YS, Ho JJ, Kim YS, Tanaka H, Nakata B, Hiura A, Motoyoshi H, Satake K, Umeyama K.
The detection of human pancreatic cancer-associated antigen in the serum of cancer patients.
Cancer. 1987 Oct 1;60(7):1636-43
PMID: 3476183
11 Koprowski H, Herlyn M, Steplewski Z, Sears HF.
Specific antigen in serum of patients with colon carcinoma.
Science. 1981 Apr 3;212(4490):53-5
PMID: 6163212