A2B5

Antibody IDAN0214
Epitope ID EP0032
Epitope nameC-Series Gangliosides Oligosaccharide / Hemato- or Ganglio-Type
Recognition regionNeu5Ac(a2-8)Neu5Ac(a2-8)Neu5Ac(a2-3)Gal-R
Neu5Ac9Ac(a2-8)Neu5Ac(a2-8)Neu5Ac(a2-3)Gal-R
Immunoprecipitation
Immunoblot[1*][2][3][4][5]
ELISA/RIA
Flow cytometry
Histochemistry
Comment
Epitope ID EP0033
Epitope nameC-Series Gangliosides Oligosaccharide / Gangliotetraosyl Core Structure
Recognition regionNeu5Ac(a2-8)Neu5Ac(a2-8)Neu5Ac(a2-3)Gal-R
Neu5Ac9Ac(a2-8)Neu5Ac(a2-8)Neu5Ac(a2-3)Gal-R
Immunoprecipitation
Immunoblot[1*][2][3][4][5]
ELISA/RIA
Flow cytometry
Histochemistry
Comment
Epitope ID EP0070
Epitope nameGT3
Recognition regionNeu5Ac(a2-8)Neu5Ac(a2-8)Neu5Ac(a2-3)Gal-R
Neu5Ac9Ac(a2-8)Neu5Ac(a2-8)Neu5Ac(a2-3)Gal-R
Immunoprecipitation
Immunoblot[1*][2][3]
ELISA/RIA
Flow cytometry
Histochemistry
Comment
SpeciesMouse
CategoryMonoclonal
IsotypeIgM
Immunogen
AvailabilityATCC
Applications
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1 Dubois C, Manuguerra JC, Hauttecoeur B, Maze J.
Monoclonal antibody A2B5, which detects cell surface antigens, binds to ganglioside GT3 (II3 (NeuAc)3LacCer) and to its 9-O-acetylated derivative.
J Biol Chem. 1990 Feb 15;265(5):2797-803
PMID: 2303428
2 Saito M, Ito M, Sugiyama K.
A specific loss of C-series gangliosides in pancreas of streptozotocin-induced diabetic rats.
Life Sci. 1999 ;64(20):1803-10
PMID: 10350354
3 Saito M, Sugiyama K.
A distinct ganglioside composition of rat pancreatic islets.
Arch Biochem Biophys. 2000 Apr 15;376(2):371-6
PMID: 10775425
4 Saito M, Kitamura H, Sugiyama K.
The specificity of monoclonal antibody A2B5 to c-series gangliosides.
J Neurochem. 2001 Jul ;78(1):64-74
PMID: 11432974
5 Nakamura K, Kojima H, Suzuki M, Suzuki A, Tamai Y.
Novel polysialogangliosides of skate brain structural determination of tetra, penta and hexasialogangliosides with a NeuAc-GalNAc linkage.
Eur J Biochem. 2000 Aug ;267(16):5198-208
PMID: 10931205