NS19-9
| Antibody ID | AN0107 |
|---|
| Epitope ID | EP0008 |
|---|---|
| Epitope name | Sialyl Lewis a |
| Recognition region | Neu5Ac(a2-3)Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-)-R |
| Immunoprecipitation | |
| Immunoblot | [4][8][7] |
| ELISA/RIA | [5*][7][6][9] |
| Flow cytometry | |
| Histochemistry | [1][2][10] |
| Comment |
| Species | Mouse |
|---|---|
| Category | Monoclonal |
| Isotype | IgG1 |
| Immunogen | SW1116/human colon adenocarcinoma[11][3] |
| Availability | TFB,INC. |
| Applications | The monoclonal antibody NS 19-9 is a representative diagnostic agent for pancreatic adenocarcinoma and cholangiocellular cancer. |
| 1 | Nakayama T, Watanabe M, Katsumata T, Teramoto T, Kitajima M. Expression of sialyl Lewis(a) as a new prognostic factor for patients with advanced colorectal carcinoma. Cancer. 1995 Apr 15;75(8):2051-6 PMID: 7697593 |
|---|---|
| 2 | Macdonald F, Bird R, Stokes H, Russell B, Crocker J. Expression of CEA, CA125, CA19-9 and human milk fat globule membrane antigen in ovarian tumours. J Clin Pathol. 1988 Mar ;41(3):260-4 PMID: 3162916 |
| 3 | Magnani JL, Nilsson B, Brockhaus M, Zopf D, Steplewski Z, Koprowski H, Ginsburg V. A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II. J Biol Chem. 1982 Dec 10;257(23):14365-9 PMID: 7142214 |
| 4 | Chang TH, Steplewski Z, Sears HF, Koprowski H. Detection of monoclonal antibody-defined colorectal carcinoma antigen by solid-phase binding inhibition radioimmunoassay. Hybridoma. 1981 ;1(1):37-45 PMID: 6926850 |
| 5 | Kitagawa H, Nakada H, Numata Y, Kurosaka A, Fukui S, Funakoshi I, Kawasaki T, Shimada I, Inagaki F, Yamashina I. Occurrence of tetra- and pentasaccharides with the sialyl-Le(a) structure in human milk. J Biol Chem. 1990 Mar 25;265(9):4859-62 PMID: 2318868 |
| 6 | Kannagi R, Takada A, Shigeta K, Itai S, Hashimoto K. [2D3 series, MSW 113 and other monoclonal antibodies directed to type 1 chain carbohydrate antigens] Nippon Rinsho. 1990 Feb ;48 Suppl:992-8 PMID: 2355641 |
| 7 | Fukuta S, Magnani JL, Gaur PK, Ginsburg V. Monoclonal antibody CC3C195, which detects cancer-associated antigens in serum, binds to the human Lea blood group antigen and to its sialylated derivative. Arch Biochem Biophys. 1987 May 15;255(1):214-6 PMID: 3592664 |
| 8 | Kano Y, Taniguchi T, Uemura Y, Yokoyama K, Ohyanagi H, Saitoh Y. Selection of monoclonal antibodies detecting KM01 antigen. Tohoku J Exp Med. 1990 Oct ;162(2):127-36 PMID: 2097812 |
| 9 | Kitagawa H, Nakada H, Numata Y, Kurosaka A, Fukui S, Funakoshi I, Kawasaki T, Yamashina I. A monoclonal antibody that recognizes sialyl-Lea oligosaccharide, but is distinct from NS 19-9 as to epitope recognition. J Biochem. 1988 Nov ;104(5):817-21 PMID: 2466827 |
| 10 | Chung YS, Ho JJ, Kim YS, Tanaka H, Nakata B, Hiura A, Motoyoshi H, Satake K, Umeyama K. The detection of human pancreatic cancer-associated antigen in the serum of cancer patients. Cancer. 1987 Oct 1;60(7):1636-43 PMID: 3476183 |
| 11 | Koprowski H, Herlyn M, Steplewski Z, Sears HF. Specific antigen in serum of patients with colon carcinoma. Science. 1981 Apr 3;212(4490):53-5 PMID: 6163212 |