WGHS-29-1

Antibody IDAN0550
Epitope ID EP0011
Epitope nameLewis x
Recognition regionGal(b1-4)[Fuc(a1-3)]GlcNAc(b1-)-R
Immunoprecipitation
Immunoblot[1*][2][3]
ELISA/RIA
Flow cytometry
Histochemistry
Comment
SpeciesMouse
CategoryMonoclonal
IsotypeIgM
Immunogen
Availability
Applications
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1 Holmes EH, Hakomori S, Ostrander GK.
Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed beta 1----3N-acetylglucosaminyltransferase.
J Biol Chem. 1987 Nov 15;262(32):15649-58
PMID: 2960671
3 Holmes EH, Ostrander GK, Clausen H, Graem N.
Oncofetal expression of Lex carbohydrate antigens in human colonic adenocarcinomas. Regulation through type 2 core chain synthesis rather than fucosylation.
J Biol Chem. 1987 Aug 15;262(23):11331-8
PMID: 3112156
2 Huang LC, Brockhaus M, Magnani JL, Cuttitta F, Rosen S, Minna JD, Ginsburg V.
Many monoclonal antibodies with an apparent specificity for certain lung cancers are directed against a sugar sequence found in lacto-N-fucopentaose III.
Arch Biochem Biophys. 1983 Jan ;220(1):318-20
PMID: 6830241