GlycoEpitope: show

6,6'- Disulfo Sialyl Lewis x

Epitope information of EP0016

Epitope ID	EP0016
Epitope name	6,6'- Disulfo Sialyl Lewis x
Structure
Sequence	Neu5Ac(a2-3)[HSO3(-6)]Gal(b1-4)[Fuc(a1-3)][HSO3(-6)]GlcNAc(b1-)-R
Aliases	6,6'-Disulfo Sialyl Le^x
History	6'- Sulfo Sialyl Le^x and 6,6'- Disulfo Sialyl Le^x are L-selectin ligand on HEV of mice.[11 *][12] The term Lewis refers to the family name of individuals suffering from a red blood cell incompatibility problem that helped lead to the discovery of this blood group.
DB	GlyTouCan:G00659GQ
Molecular weight	980.9
Composition	(Fuc)1(Gal)1(GlcNAc)1(Neu5Ac)1(HSO3)2
Species	Mus musculus
Tissue and Cellular distribution	HEV(mouse)
Subcellular distribution
Developmental change
Cell line
Receptor	L-selectin(mouse)(The hierarchy of binding strengths were 6-sulfo sialyl > sialyl = 6',6-bis-sulfo sialyl >> 6'-sulfo sialyl Le^x.)[23][12][11 *]
Function	lymphocyte homing
Diseases
Application
Comment

Epitope ID

EP0016

Epitope name

6,6'- Disulfo Sialyl Lewis x

Structure

Sequence

Neu5Ac(a2-3)[HSO3(-6)]Gal(b1-4)[Fuc(a1-3)][HSO3(-6)]GlcNAc(b1-)-R

Aliases

6,6'-Disulfo Sialyl Le^x

History

6'- Sulfo Sialyl Le^x and 6,6'- Disulfo Sialyl Le^x are L-selectin ligand on HEV of mice.[11 *][12]
The term Lewis refers to the family name of individuals suffering from a red blood cell incompatibility problem that helped lead to the discovery of this blood group.

GlyTouCan:G00659GQ

Molecular weight

980.9

Composition

(Fuc)1(Gal)1(GlcNAc)1(Neu5Ac)1(HSO3)2

Species

Mus musculus

Tissue and Cellular distribution

HEV(mouse)

Subcellular distribution

Developmental change

Cell line

Receptor

L-selectin(mouse)(The hierarchy of binding strengths were 6-sulfo sialyl > sialyl = 6',6-bis-sulfo sialyl >> 6'-sulfo sialyl Le^x.)[23][12][11 *]

Function

lymphocyte homing

Diseases

Application

Comment