6,6'- Disulfo Sialyl Lewis x

General | Antibody | Glycoprotein | Glycolipid | Enzyme | Reference

Epitope information of EP0016

Epitope IDEP0016
Epitope name6,6'- Disulfo Sialyl Lewis x
Structure
SequenceNeu5Ac(a2-3)[HSO3(-6)]Gal(b1-4)[Fuc(a1-3)][HSO3(-6)]GlcNAc(b1-)-R
Aliases6,6'-Disulfo Sialyl Lex
History6'- Sulfo Sialyl Lex and 6,6'- Disulfo Sialyl Lex are L-selectin ligand on HEV of mice.[11*][12]
The term Lewis refers to the family name of individuals suffering from a red blood cell incompatibility problem that helped lead to the discovery of this blood group.
DB GlyTouCan:G00659GQ
Molecular weight980.9
Composition(Fuc)1(Gal)1(GlcNAc)1(Neu5Ac)1(HSO3)2
Species

Mus musculus

Tissue and Cellular distribution

HEV(mouse)

Subcellular distribution

Developmental change

Cell line

Receptor

L-selectin(mouse)(The hierarchy of binding strengths were 6-sulfo sialyl > sialyl = 6',6-bis-sulfo sialyl >> 6'-sulfo sialyl Lex.)[23][12][11*]

Function

lymphocyte homing

Diseases

Application
Comment