GlycoEpitope: show

Lewis y

Epitope information of EP0018

Epitope ID	EP0018
Epitope name	Lewis y
Structure
Sequence	Fuc(a1-2)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-)-R
Aliases	Le^y,CD174, Y-hapten
History	Lewis antigens and their derivatives such as Le^b,Le^x,sialyl Le^x,sialyl Le^a,and Le^y were identified as tumor-associated structures approximately 20 years ago using hybridoma technology and showed that upregulation and/or de novo expression of these determinants on the tumor cell surface is associated with a poor prognosis.[5]
DB	PDB:1S3K GlyTouCan:G00052MO JCGGDB
Molecular weight	675.6
Composition	(Fuc)2(Gal)1(GlcNAc)1
Species	Homo sapiens
Tissue and Cellular distribution	cancer/ovary[2] vascular endothelium erythroid granulocyte hematopoietic progenitor cell normal epithelia/breast[33] normal epithelia/oral cavity[33]
Subcellular distribution
Developmental change	The Le^y(CD174) are expressed on CD34+ hematopoietic progenitors but absent on mature lymphocytes and CD34- cell lines.[3]
Cell line	KG1 (CD34+ leukemia cell line)[3] KG1a (CD34+ leukemia cell line)[3] TF1 (CD34+ leukemia cell line)[3]
Receptor
Function	The expression of the fucosylated histo-blood group antigen CD174 in CD34+ hematopoietic progenitor cells and down-regulation of FUT1 in mature lymphocytes may be important factors influencing the homing process of hematopoietic stem cells to the bone marrow.[3]
Diseases	AIDS/acquired immune deficiency syndrome[4] cholangiocarcinoma[6] hepatocellular carcinoma[6] Inappropriate tissue distribution of Le^y blood-group antigens was observed in CCs(cholangiocarcinomas) and, much less frequently, in HCCs(hepatocellular carcinomas).[6] Le^y determinant is highly expressed in human immunodeficiency virus (HIV)-infected T cell lines and in CD3+ peripheral mature T cells of patients with acquired immune deficiency syndrome (AIDS) or with AIDS-related complex (ARC).[4]
Application	The Lewis antigen is expression in pancreatic cancer cells and may be useful as a tumor marker.[7]
Comment

Epitope ID

EP0018

Epitope name

Lewis y

Structure

Sequence

Fuc(a1-2)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-)-R

Aliases

Le^y,CD174, Y-hapten

History

Lewis antigens and their derivatives such as Le^b,Le^x,sialyl Le^x,sialyl Le^a,and Le^y were identified as tumor-associated structures approximately 20 years ago using hybridoma technology and showed that upregulation and/or de novo expression of these determinants on the tumor cell surface is associated with a poor prognosis.[5]

PDB:1S3K GlyTouCan:G00052MO JCGGDB

Molecular weight

675.6

Composition

(Fuc)2(Gal)1(GlcNAc)1

Species

Homo sapiens

Tissue and Cellular distribution

cancer/ovary[2]
vascular endothelium
erythroid
granulocyte
hematopoietic progenitor cell
normal epithelia/breast[33]
normal epithelia/oral cavity[33]

Subcellular distribution

Developmental change

The Le^y(CD174) are expressed on CD34+ hematopoietic progenitors but absent on mature lymphocytes and CD34- cell lines.[3]

Cell line

KG1 (CD34+ leukemia cell line)[3]
KG1a (CD34+ leukemia cell line)[3]
TF1 (CD34+ leukemia cell line)[3]

Receptor

Function

The expression of the fucosylated histo-blood group antigen CD174 in CD34+ hematopoietic progenitor cells and down-regulation of FUT1 in mature lymphocytes may be important factors influencing the homing process of hematopoietic stem cells to the bone marrow.[3]

Diseases

AIDS/acquired immune deficiency syndrome[4]
cholangiocarcinoma[6]
hepatocellular carcinoma[6]

Inappropriate tissue distribution of Le^y blood-group antigens was observed in CCs(cholangiocarcinomas) and, much less frequently, in HCCs(hepatocellular carcinomas).[6]
Le^y determinant is highly expressed in human immunodeficiency virus (HIV)-infected T cell lines and in CD3+ peripheral mature T cells of patients with acquired immune deficiency syndrome (AIDS) or with AIDS-related complex (ARC).[4]

Application

The Lewis antigen is expression in pancreatic cancer cells and may be useful as a tumor marker.[7]

Comment