Sialyl 6-Sulfo Lewis x
General | Antibody | Glycoprotein | Glycolipid | Enzyme | ReferenceEpitope information of EP0015
| Epitope ID | EP0015 |
|---|---|
| Epitope name | Sialyl 6-Sulfo Lewis x |
| Structure |  |
| Sequence | Neu5Ac(a2-3)Gal(b1-4)[Fuc(a1-3)][HSO3(-6)]GlcNAc(b1-)-R |
| Aliases | Sialyl 6-Sulfo Lex,formerly 6-Sulfo Sialyl Lex |
| History | The epitope was found to be a specific ligand for L-selectin present in high endothelial venules of human peripheral lymph nodes, and was shown to mediate homing of naive lymphocytes. [11] The term Lewis refers to the family name of individuals suffering from a red blood cell incompatibility problem that helped lead to the discovery of this blood group. |
| DB | GlyTouCan:G80722US |
| Molecular weight | 900.8 |
| Composition | (Fuc)1(Gal)1(GlcNAc)1(Neu5Ac)1(HSO3)1 |
| Species | |
| Tissue and Cellular distribution | high endothelial venule(human) |
| Subcellular distribution | |
| Developmental change | |
| Cell line | |
| Receptor | L-selectin(The hierarchy of binding strengths were 6-sulfo sialyl > sialyl = 6',6-bis-sulfo sialyl >> 6'-sulfo sialyl Lex.)[24] |
| Function | |
| Diseases | |
| Application | |
| Comment |