| Epitope ID | EP0022 |
| Epitope name | Sialyl Tn Antigen |
| Structure |  |
| Sequence | Neu5Ac(a2-6)GalNAc(a1-)Ser/Thr |
| Aliases | |
| History | Red blood cells of blood group Tn were later found to coexpress sialyl Tn antigen,which is considered as a rare histo-blood group antigen. |
| DB |
GlyTouCan:G36123IU
|
| Molecular weight | 512.5(Ser/Thr) |
| Composition | (Neu5Ac)1(GalNAc)1(Ser/Thr)1 |
| Species | Fasciola hepatica[7]
Homo sapiens
Human Immunodeficiency Virus[9]
Mesocestoides vogae[90]
Rattus norvegicus[6]
Trypanosoma cruzi[8] |
| Tissue and Cellular distribution | ACF/aberrant crypt foci[103]
B cell
cancer/bladder [49]
cancer/breast [2][3][21][22][23][24][25][26][55][104]
cancer/colon[51][52]
cancer/colon(rat)[53]
cancer/colon(rat)(DMH induced)[84]
cancer/colorectal [10][11][12][13][14][1][15][16][17][18][19][20][54][105]
cancer/esophageal [50][5]
cancer/liver [4]
cancer/iterome cancer [46][47][48]
cancer/pancreas[38][39]
cancer/stomach[27][28][29][30][31][32][33][34][35][36][37]
epithelial cell/bronchi(ferret)[89]
epithelial cell/uterine cervical[46]
erythroblastic cell
intestinal metaplasia[85]
malignant prostatic gland[106]
metaplasia mucosa/stomach[107]
normal colonic mucosa[14]
normal epithelia/oral cavity[97]
normal/duodenum[53]
normal/gonocyte[89]
normal/ileum[53]
normal/jejunum[53]
prostate intraepithelial neoplasia[106]
serum[93]
tumor/anaplastic meningioma[75]
tumor/ovary[40][41][42][43][44][45] |
| Subcellular distribution | goalec cell vacuoles/cytoplasm of columnar cells[72]
Golgi compartment and RER/human colorectal cancer[69]
trans-Golgi apparatus/human colorectal adenoma[69] |
| Developmental change | as early as nine weeks of gastation[72]
slight increase between 12 and 28 days of differenciation in BG01 human embryonic stem cells[98]
Gonocytes expressed abundant sialyl-Tn and sialyl-T, and adult spermatogonia were devoid. [89] |
| Cell line | EEB/erythroblastic leukemia[86]
HEL/human erythroleukemia
HMA-1/human breast carcinoma[55]
HT-29/human colon adenocarcinoma[52]
K562/human erythromyeloblastoid leukemia
LMCR/rat colon adenocarcinoma[53]
LS174T/human colon adenocarcinoma[51]
LS180/human colon adenocarcinoma[54]
LSC/human colon cancer[76]
MCF-7/human breast adenocarcinoma |
| Receptor | Siglec-6[56*][57*] |
| Function | apoptosis of monocyte-derived dendritic cells[91]
decrease of adhesion and increase of migration[92][108]
increase of tumor growth[92][108]
associated with morphological changes, decreased growth and increased migration of MDA-MB-231 cells[102] |
| Diseases | anaplastic meningioma[75]
Barrett's esophagus [94]
bladder cancer[49]
breast cancer[2][3][21][22][23][24][25][26]
colon cancer[51][52][53][84][93]
colorectal cancer[10][11][12][13][14][1][15][16][17][18][19][20]
erythroblastic leukemia[86]
esophageal cancer[50][5]
gastric cancer[27][28][29][30][31][32][33][34][35][36][37]
helicobacter pylori chronic gastritis(HpCG)[70]
liver cancer[4]
iterome cancer[46][47][48]
ovary tumor[40][41][42][43][44][45]
pancreas cancer[38][39] |
| Application | tumor marker[109] |
| Comment | |
