SSEA-1
General | Antibody | Glycoprotein | Glycolipid | Enzyme | ReferenceEpitope information of EP0042
| Epitope ID | EP0042 |
|---|---|
| Epitope name | SSEA-1 |
| Structure |  |
| Sequence | Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-)-R |
| Aliases | stage specific embryonic antigen-1 / Lex-i / X-i hapten |
| History | The carbohydrate determinant having this terminal structure was identified as the specific antigen recognized by an antibody directed to murine developmental antigen SSEA-1.[5][1][6*][2][7] |
| DB | GlyTouCan:G85497PI JCGGDB |
| Molecular weight | 1057.0 |
| Composition | (Fuc)1(Gal)3(GlcNAc)2 |
| Species | Homo sapiens |
| Tissue and Cellular distribution | cancer cell(human) |
| Subcellular distribution | |
| Developmental change | Appears at morula stage and disappear thereafter in murine preimplantation embryos.[7][8][9][10] |
| Cell line | F9/mouse embryonal carcinoma |
| Receptor | |
| Function | This determinant is specifically recognized by the antibody raised against stage-specific embryonic antigen-1 (SSEA-1). The SSEA-1 antibody requires Lex hapten carried by i-antigenic structure (e.g.,nor-nLc6Cer). |
| Diseases | |
| Application | Purification of murine embryonic stem cells.[11][12] |
| Comment |