Poly-N-Acetylneuraminic Acid

General | Antibody | Glycoprotein | Glycolipid | Enzyme | Reference

Epitope information of EP0101

Epitope IDEP0101
Epitope namePoly-N-Acetylneuraminic Acid
Structure
Sequence(Neu5Ac) n
AliasesPolysialic acid
HistoryMembranous sialyltransferase complexes from Escherichia coli K-235 catalyze the synthesis of surface polymers containing alpha-2,8-ketosidically linked polysialic acid.[7*]
DB GlyTouCan:G80631ZD
Molecular weight
Composition(Neu5Acn)1
Species

Tissue and Cellular distribution

cancer cell
cancer/neuroblastoma
cancer/small- cell lung cancer (SCLC)

Subcellular distribution

Developmental change

Cell line

CHP-134/human neuroblastoma

Receptor

Function

Polysialic acid chains on neural cell adhesion molecule (NCAM) present this homotypic interaction, are anti-adhesive and change shape. Cell migration and axon development during brain development are thus associated with polysialation of NCAM.[8]

Diseases

neuroblastoma
small cell lung cancer

Application
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