Epitope ID | EP0022 |
Epitope name | Sialyl Tn Antigen |
Structure | |
Sequence | Neu5Ac(a2-6)GalNAc(a1-)Ser/Thr |
Aliases | |
History | Red blood cells of blood group Tn were later found to coexpress sialyl Tn antigen,which is considered as a rare histo-blood group antigen. |
DB |
GlyTouCan:G36123IU
|
Molecular weight | 512.5(Ser/Thr) |
Composition | (Neu5Ac)1(GalNAc)1(Ser/Thr)1 |
Species | Fasciola hepatica[7] Homo sapiens Human Immunodeficiency Virus[9] Mesocestoides vogae[90] Rattus norvegicus[6] Trypanosoma cruzi[8] |
Tissue and Cellular distribution | ACF/aberrant crypt foci[103] B cell cancer/bladder [49] cancer/breast [2][3][21][22][23][24][25][26][55][104] cancer/colon[51][52] cancer/colon(rat)[53] cancer/colon(rat)(DMH induced)[84] cancer/colorectal [10][11][12][13][14][1][15][16][17][18][19][20][54][105] cancer/esophageal [50][5] cancer/liver [4] cancer/iterome cancer [46][47][48] cancer/pancreas[38][39] cancer/stomach[27][28][29][30][31][32][33][34][35][36][37] epithelial cell/bronchi(ferret)[89] epithelial cell/uterine cervical[46] erythroblastic cell intestinal metaplasia[85] malignant prostatic gland[106] metaplasia mucosa/stomach[107] normal colonic mucosa[14] normal epithelia/oral cavity[97] normal/duodenum[53] normal/gonocyte[89] normal/ileum[53] normal/jejunum[53] prostate intraepithelial neoplasia[106] serum[93] tumor/anaplastic meningioma[75] tumor/ovary[40][41][42][43][44][45] |
Subcellular distribution | goalec cell vacuoles/cytoplasm of columnar cells[72] Golgi compartment and RER/human colorectal cancer[69] trans-Golgi apparatus/human colorectal adenoma[69] |
Developmental change | as early as nine weeks of gastation[72] slight increase between 12 and 28 days of differenciation in BG01 human embryonic stem cells[98] Gonocytes expressed abundant sialyl-Tn and sialyl-T, and adult spermatogonia were devoid. [89] |
Cell line | EEB/erythroblastic leukemia[86] HEL/human erythroleukemia HMA-1/human breast carcinoma[55] HT-29/human colon adenocarcinoma[52] K562/human erythromyeloblastoid leukemia LMCR/rat colon adenocarcinoma[53] LS174T/human colon adenocarcinoma[51] LS180/human colon adenocarcinoma[54] LSC/human colon cancer[76] MCF-7/human breast adenocarcinoma |
Receptor | Siglec-6[56*][57*] |
Function | apoptosis of monocyte-derived dendritic cells[91] decrease of adhesion and increase of migration[92][108] increase of tumor growth[92][108] associated with morphological changes, decreased growth and increased migration of MDA-MB-231 cells[102] |
Diseases | anaplastic meningioma[75] Barrett's esophagus [94] bladder cancer[49] breast cancer[2][3][21][22][23][24][25][26] colon cancer[51][52][53][84][93] colorectal cancer[10][11][12][13][14][1][15][16][17][18][19][20] erythroblastic leukemia[86] esophageal cancer[50][5] gastric cancer[27][28][29][30][31][32][33][34][35][36][37] helicobacter pylori chronic gastritis(HpCG)[70] liver cancer[4] iterome cancer[46][47][48] ovary tumor[40][41][42][43][44][45] pancreas cancer[38][39] |
Application | tumor marker[109] |
Comment | |