Sialyl 6-Sulfo Lewis x

General | Antibody | Glycoprotein | Glycolipid | Enzyme | Reference

5 biosynthetic enzyme for EP0015

NameReaction
GlcNAc6ST-1,HEC-GlcNAc6ST GlcNAc(b1-)-R + PAPS = HSO3(-6)GlcNAc(b1-)-R + PAP
Beta4GalT HSO3(-6)GlcNAc(b1-)-R + UDP-Gal = Gal(b1-4)[HSO3(-6)]GlcNAc(b1-)-R + UDP
ST3Gal Gal(b1-4)[HSO3(-6)]GlcNAc(b1-)-R + CMP-Neu5Ac = Neu5Ac(a2-3)Gal(b1-4)[HSO3(-6)]GlcNAc(b1-)-R + CMP
FUT7 Neu5Ac(a2-3)Gal(b1-4)[HSO3(-6)]GlcNAc(b1-)-R + GDP-Fuc = Neu5Ac(a2-3)Gal(b1-4)[Fuc(a1-3)][HSO3(-6)]GlcNAc(b1-)-R + GDP
NameGlcNAc6ST-1
ReactionGlcNAc(b1-)-R + PAPS = HSO3(-6)GlcNAc(b1-)-R + PAP
DescriptionCHST2 / carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 2 / GST-2EC[10200296][9712885(http://www.jbc.org/cgi/reprint/273/35/22577)]
ECEC 2.8.2.-
DBNCBI/Gene Swissprot/TrEMBL
Gene deficient organisms[10*]
Comment
NameHEC-GlcNAc6ST
ReactionGlcNAc(b1-)-R + PAPS = HSO3(-6)GlcNAc(b1-)-R + PAP
DescriptionCHST4 / carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 / GST-3 / GlcNAc6ST-2 / LSST
ECEC 2.8.2.-
DBNCBI/Gene Swissprot/TrEMBL
Gene deficient organisms[17][18][10*]
Comment
NameBeta4GalT
ReactionHSO3(-6)GlcNAc(b1-)-R + UDP-Gal = Gal(b1-4)[HSO3(-6)]GlcNAc(b1-)-R + UDP
Descriptionbeta1,4-galactosyltransferase
ECEC 2.4.1.90
DBNCBI/Gene Swissprot/TrEMBL PDB CAZy:GT7
Gene deficient organisms
Comment
NameST3Gal
ReactionGal(b1-4)[HSO3(-6)]GlcNAc(b1-)-R + CMP-Neu5Ac = Neu5Ac(a2-3)Gal(b1-4)[HSO3(-6)]GlcNAc(b1-)-R + CMP
DescriptionGal beta(1-3/1-4)GlcNAc alpha2,3-Sialyltransferase
ECEC 2.4.99.-
DBNCBI/Gene Swissprot/TrEMBL CAZy:GT29
Gene deficient organisms
Comment
NameFUT7
ReactionNeu5Ac(a2-3)Gal(b1-4)[HSO3(-6)]GlcNAc(b1-)-R + GDP-Fuc = Neu5Ac(a2-3)Gal(b1-4)[Fuc(a1-3)][HSO3(-6)]GlcNAc(b1-)-R + GDP
Descriptionalpha-1,3-Fucosyltransferase / fucosyltransferase VII[10200296]
ECEC 2.4.1.152
DBNCBI/Gene Swissprot/TrEMBL CAZy:GT37
Gene deficient organisms
Comment

0 degradation enzyme for EP0015